Evaluation of chlorothiazide alone in the treatment of moderately severe and severe hypertension.

j 1 demonstrated the potentiation of antihypertensive agents by chlorothiazide,1-3 its value alone in patients with moderately severe and severe hypertension has not been established. This investigation was designed to compare the effectiveness of alternate 6-month courses of chlorothiazide alone with standard antihypertensive therapy, and to compare the results of these periods with those of a 6month combined treatment period when patients received both chlorothiazide plus standard antihypertensive therapy.